KORNBRUST, DOUGLAS J.: search on Z-Library

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1

Toxicological and Pharmacokinetic Properties of QPI-1007, a Chemically Modified Synthetic siRNA Targeting Caspase 2 mRNA, Following Intravitreal Injection

Solano, Elisabeth C.R., Kornbrust, Douglas J., Beaudry, Amber, Foy, Jeffrey W.-D., Schneider, David J., Thompson, James D.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2014

Language:

english

File:

PDF, 190 KB

english, 2014

2

Association of inhaled [14C]methyl chloride with macromolecules from various rat tissues

Douglas J. Kornbrust, James S. Bus, Gerhard Doerjer, J.A. Swenberg

Journal:

Toxicology and Applied Pharmacology

Year:

1982

Language:

english

File:

PDF, 1.33 MB

english, 1982

3

Assessing unintended hybridization-induced biological effects of oligonucleotides

Lindow, Morten, Vornlocher, Hans-Peter, Riley, Donald, Kornbrust, Douglas J, Burchard, Julja, Whiteley, Laurence O, Kamens, Joanne, Thompson, James D, Nochur, Saraswathy, Younis, Husam, Bartz, Steven,

Journal:

Nature Biotechnology

Year:

2012

Language:

english

File:

PDF, 222 KB

english, 2012

4

Recommendations of the Oligonucleotide Safety Working Group's Formulated Oligonucleotide Subcommittee for the Safety Assessment of Formulated Oligonucleotide-Based Therapeutics

Marlowe, Jennifer L., Akopian, Violetta, Karmali, Priya, Kornbrust, Douglas, Lockridge, Jennifer, Semple, Sean

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2017

Language:

english

File:

PDF, 275 KB

english, 2017

5

Effects of pretreatment with pyrazole and inducers of mixed function oxidases on DNA repair elicited by dimethylnitrosamine in rat hepatocytes in vivo and in vitro

Douglas Kornbrust, Dennis Dietz

Journal:

Chemico-Biological Interactions

Year:

1985

Language:

english

File:

PDF, 895 KB

english, 1985

6

First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder

Leachman, Sancy A, Hickerson, Robyn P, Schwartz, Mary E, Bullough, Emily E, Hutcherson, Stephen L, Boucher, Kenneth M, Hansen, C David, Eliason, Mark J, Srivatsa, G Susan, Kornbrust, Douglas J, Smith,

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 264 KB

english, 2010

7

Recommendations for Safety Pharmacology Evaluations of Oligonucleotide-Based Therapeutics

Berman, Cindy L., Cannon, Keri, Cui, Yi, Kornbrust, Douglas J., Lagrutta, Armando, Sun, Sunny Z., Tepper, Jeff, Waldron, Gareth, Younis, Husam S.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2014

Language:

english

File:

PDF, 303 KB

english, 2014

8

Thiobenzamide-induced hepatotoxicity: Effects of substituents and route of administration on the nature and extent of liver injury

Scott J. Grossman, Darryl H. Patrick, Douglas Kornbrust, Peter F. Smith, Eugene G. Herold, John G. DeLuca, Anthony G. Zacchei

Journal:

Toxicology and Applied Pharmacology

Year:

1991

Language:

english

File:

PDF, 15.40 MB

english, 1991

9

Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys

Scott P. Henry, Henry Bolte, Carol Auletta, Douglas J. Kornbrust

Journal:

Year:

1997

Language:

english

File:

PDF, 1.05 MB

english, 1997

10

Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats

Scott P. Henry, Lisa R. Grillone, Jack L. Orr, Richard H. Bruner, Douglas J. Kornbrust

Journal:

Year:

1997

Language:

english

File:

PDF, 1.07 MB

english, 1997

11

Metabolism of methyl chloride to formate in rats

Douglas J. Kornbrust, James S. Bus

Journal:

Toxicology and Applied Pharmacology

Year:

1982

Language:

english

File:

PDF, 718 KB

english, 1982

12

The effect of paraquat on microsomal lipid peroxidation in vitro and in vivo

Douglas J. Kornbrust, Richard D. Mavis

Journal:

Toxicology and Applied Pharmacology

Year:

1980

Language:

english

File:

PDF, 857 KB

english, 1980

13

Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide

Scott P Henry, Greg Beattie, Grace Yeh, Alfred Chappel, Patricia Giclas, Angela Mortari, Mark A Jagels, Douglas J Kornbrust, Arthur A Levin

Journal:

International Immunopharmacology

Year:

2002

Language:

english

File:

PDF, 160 KB

english, 2002

14

Inhibition of Coagulation by a Phosphorothioate Oligonucleotide

HENRY, SCOTT P., NOVOTNY, WILLIAM, LEEDS, JANET, AULETTA, CAROL, KORNBRUST, DOUGLAS J.

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1997

Language:

english

File:

PDF, 2.56 MB

english, 1997

15

Glutathione depletion by methyl chloride and association with lipid peroxidation in mice and rats

Douglas J. Kornbrust, James S. Bus

Journal:

Toxicology and Applied Pharmacology

Year:

1984

Language:

english

File:

PDF, 1.07 MB

english, 1984

16

Subchronic Toxicity Studies with the Leukotriene D 4 Antagonist RG 12525

BONNEFOI, MARC S., KELLEY, MICHAEL F., WELLS, ROGER E., SANDERS, JAMES E., JAYYOSI, ZAID, BEYS, ERIC, KORNBRUST, DOUGLAS J., LANGLOSS, ZAID

Journal:

Toxicological Sciences

Year:

1995

Language:

english

File:

PDF, 6.16 MB

english, 1995

17

Investigations of the Potential for Five β-Lactam Antibiotics to Elicit Type II Hypersensitivity Reactions in Rats and Monkeys

KORNBRUST, DOUGLAS, EYDELLOTH, RONALD, GARRATTY, GEORGE

Journal:

Toxicological Sciences

Year:

1989

Language:

english

File:

PDF, 595 KB

english, 1989

18

Preclinical evaluation of lovastatin

James S. MacDonald, Ronald J. Gerson, Douglas J. Kornbrust, Michelle W. Kloss, Srinivasa Prahalada, Peter H. Berry, Alfred W. Alberts, Delwin L. Bokelman

Journal:

The American Journal of Cardiology

Year:

1988

Language:

english

File:

PDF, 4.01 MB

english, 1988

19

Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics

Henry, Scott P., Seguin, Rosanne, Cavagnaro, Joy, Berman, Cindy, Tepper, Jeff, Kornbrust, Douglas

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2016

Language:

english

File:

PDF, 152 KB

english, 2016

20

The role of glutathione and cytochrome P-450 in the metabolism of methyl chloride

Douglas J. Kornbrust, James S. Bus

Journal:

Toxicology and Applied Pharmacology

Year:

1983

Language:

english

File:

PDF, 1.42 MB

english, 1983

21

Aroclor 1254 pretreatment effects on DNA repair in rat hepatocytes elicited by in vivo or in vitro exposure to various chemicals

Douglas Kornbrust, Dennis Dietz

Journal:

Environmental and Molecular Mutagenesis

Year:

1985

Language:

english

File:

PDF, 979 KB

english, 1985

22

Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme a reductase inhibitors

Ronald J. Gerson, James S. Macdonald, Albert W. Alberts, Douglas J. Kornbrust, James A. Majka, R. John Stubbs, Delwin L. Bokelman

Journal:

The American Journal of Medicine

Year:

1989

Language:

english

File:

PDF, 1.25 MB

english, 1989

23

Effects of pretreatment with inducers of hepatic mixed function oxidases on DNA repair elicited by various compounds in hepatocytes from adult and neonatal rats

Douglas Kornbrust, Dennis Dietz

Journal:

Cell Biology and Toxicology

Year:

1987

Language:

english

File:

PDF, 1.35 MB

english, 1987

24

Comparison of 7 azo dyes and their azo reduction products in the rat and hamster hepatocyte primary culture/DNA-repair assays

Douglas J. Kornbrust, Thomas R. Barfknecht

Journal:

Mutation Research/Genetic Toxicology

Year:

1984

Language:

english

File:

PDF, 797 KB

english, 1984

25

Testing of 24 food, drug, cosmetic, and fabric dyes in the in vitro and the in vivo/in vitro rat hepatocyte primary culture DNA repair assays

Douglas Kornbrust, Thomas Barfknecht

Journal:

Environmental and Molecular Mutagenesis

Year:

1985

Language:

english

File:

PDF, 1.10 MB

english, 1985

26

Evaluation of the Toxicity of ISIS 2302, a Phosphorothioate Oligonucleotide, in a 4-Week Study in CD-1 Mice

HENRY, SCOTT P., TAYLOR, JACK, MIDGLEY, LEONORA, LEVIN, ARTHUR A., KORNBRUST, DOUGLAS J.

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1997

Language:

english

File:

PDF, 7.23 MB

english, 1997

27

Acute Toxicology and Pharmacokinetic Assessment of a Ribozyme (ANGIOZYME™) Targeting Vascular Endothelial Growth Factor Receptor mRNA in the Cynomolgus Monkey

SANDBERG, JENNIFER A., SPROUL, CHRISTOPHER D., BLANCHARD, KARIN S., BELLON, LAURENT, SWEEDLER, DAVID, POWELL, JAMES A., CAPUTO, FLORENCE A., KORNBRUST, DOUGLAS J., PARKER, VANN P., PARRY, TOM J., BLAT

Journal:

Antisense and Nucleic Acid Drug Development

Year:

2000

Language:

english

File:

PDF, 1.35 MB

english, 2000

28

Effects of 1,1-dichloro-2,2-BIS[p-chlorophenyl]ethylene (DDE) on lactation in rats

Kornbrust, Douglas, Gillis, Beth, Collins, Brad, Goehl, Thomas, Gupta, Bhola, Schwetz, Bernard

Journal:

Journal of Toxicology and Environmental Health

Year:

1986

Language:

english

File:

PDF, 1.03 MB

english, 1986

29

Subchronic Toxicity Studies with the Leukotriene D4 Antagonist RG 12525

Marc S. Bonnefoi, Michael F. Kelley, Roger E. Wells, James E. Sanders, Zaid Jayyosi, Eric Beys, Douglas J. Kornbrust, John M. Langloss

Journal:

Fundamental and Applied Toxicology

Year:

1995

File:

PDF, 991 KB

1995

30

Toxicity and Toxicokinetics of a Phosphorothioate Oligonucleotide Against the c- myc Oncogene in Cynomolgus Monkeys

Webb, Murray S., Tortora, Nicholas, Cremese, Michael, Kozlowska, Hanna, Blaquiere, Mado, Devine, Dana V., Kornbrust, Douglas J.

Journal:

Antisense and Nucleic Acid Drug Development

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

31

Induction of Peroxisomal Enzymes by a Tetrazole-Substituted 2-Quinolinylmethoxy Leukotriene D 4 Antagonist

KELLEY, MICHAEL, GROTH-WATSON, ANDREA, KNOBLE, DEBORAH, KORNBRUST, DOUGLAS

Journal:

Toxicological Sciences

Year:

1994

Language:

english

File:

PDF, 3.24 MB

english, 1994

32

Comparison of rat and hamster hepatocyte primary culture/DNA repair assays

Douglas J. Kornbrust, Thomas R. Barfknecht

Journal:

Environmental and Molecular Mutagenesis

Year:

1984

Language:

english

File:

PDF, 603 KB

english, 1984

33

Effect of silica and volcanic ash on the content of lung alveolar and tissue phospholipids

Douglas J. Kornbrust, Gary E. Hatch

Journal:

Environmental Research

Year:

1984

Language:

english

File:

PDF, 1.05 MB

english, 1984

34

Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: Correlation with vitamin E content

Douglas J. Kornbrust, Richard D. Mavis

Journal:

Year:

1980

Language:

english

File:

PDF, 601 KB

english, 1980

35

Induction of Peroxisomal Enzymes by a Tetrazole-Substituted 2-Quinolinylmethoxy Leukotriene D4 Antagonist

Michael Kelley, Andrea Groth-Watson, Deborah Knoble, Douglas Kornbrust

Journal:

Fundamental and Applied Toxicology

Year:

1994

File:

PDF, 356 KB

1994

36

Effect of di(2‐ethylhexyl) phthalate on dna repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster v‐79 cells

Kornbrust, Douglas J., Barfknecht, Thomas R., Ingram, Peter, Shelburne, John D.

Journal:

Journal of Toxicology and Environmental Health

Year:

1984

Language:

english

File:

PDF, 1.07 MB

english, 1984

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